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David Pina Trincão1, Miguel Paiva1, Nicole Pinto1, Elena Finelli1, Sara Prates1, Sónia Rosa1, Ana Margarida Romeira1, Paula Leiria Pinto1

1. Serviço de Imunoalergologia do Hospital de Dona Estefânia, Centro Hospitalar de Lisboa, E.P.E., Lisboa

- XXXVI Congress of the European Academy Allergology Clinical Immunology, 17-21/06/2017, Helsínquia, Finlândia
- Apresentação como poster; publicação de resumo
- Reunião Internacional

Introduction: Food protein induced enterocolitis syndrome (FPIES) is a non-IgE mediated gastrointestinal allergic disorder. Its clinical presentation encompasses non-immediate severe vomiting, diarrhea and dehydration. There are no specific biomarkers, making it a diagnostic challenge. Characterization of patients helps to provide more evidence regarding natural history and impact of this disease.
Objectives: To perform a retrospective study of children clinically diagnosed with FPIES between 2010 and 2016.
Results: 11 patients were included, seven boys and four girls, with a median age at diagnosis of six months. The most common offending foods were cow’s milk protein (CMP, n=5) and rice (n=2). Other foods were fish, egg, chicken, wheat, carrot and potato. Average time of symptom onset was 2.5 hours. The most frequent symptoms were vomiting (n=10) and diarrhea (n=4). Six patients had a history of hospital admission related to this problem. Seven patients had concomitant atopic diseases, being the most frequent allergic co-mobility atopic eczema (n=5). Skin prick tests and/or specific IgE to culprit foods were negative at diagnosis, except for one patient with low specific IgE to CMP. Another patient become sensitized to CMP during follow-up. Open food challenges were performed in 10 patients starting from six months of age. Resolution was achieved in 6 patients, at a medium age of 36 months.
Conclusions: This case series provides one more look at FPIES’ patients characterization, increasing the knowledge about this disease. FPIES is a severe disease that often leads to hospital admissions. Milk is the most frequent allergen in this series. A majority of children achieved clinical resolution at 3 years of age.

Palavras Chave: FPIES, Food allergy