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2019

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Anti-N-methyl-D-aspartate Receptor Encephalitis with Positive Serum Antithyroid Antibodies, IgM Antibodies Against Mycoplasma pneumoniae and Human Herpesvirus 7 PCR in the CSF

Paulo Venâncio1, Maria João Brito2, Gabriela Pereira1, José Pedro Vieira3

1 - Unidade de Cuidados Intensivos Pediátricos, Área de Pediatria Médica, Hospital de Dona Estefânia, CHLC, EPE
2 - Unidade de Infecciologia, Área de Pediatria Médica, Hospital de Dona Estefânia, CHLC, EPE
3 - Serviço de Neurologia Pediátrica, Hospital de Dona Estefânia, CHLC, EPE

Divulgação: publicado no Pediatric Infectious Disease Journal. 33(8):882-883, August 2014.

Resumo:
We report the case of a boy with an encephalopathy associated with extrapyramidal and psychiatric symptoms and anti-N-methyl-D-aspartate receptor antibodies. He had positive serum antithyroid antibodies, IgM antibodies against Mycoplasma pneumoniae and human herpesvirus 7 polymerase chain reaction in the cerebrospinal fluid. He was successfully treated with rituximab, after steroids, intravenous immunoglobulin and plasma exchange. The pathophysiology of this disorder may be post-infectious and autoimmune.

Keywords: encephalitis; N-methyl-D-aspartate receptor; Mycoplasma pneumoniae; HHV-7; rituximab.