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2018

ANUÁRIO DO HOSPITAL DONA ESTEFÂNIA
REPOSITÓRIO MÉDICO CIENTÍFICO

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INVASIVE PNEUMOCOCCAL DISEASE (IPD) IN CHILDREN IN PORTUGAL PROSPECTIVE STUDY (2008-2016)

Maria João Brito and The Portuguese Study Group of Invasive Pneumococcal Disease The Paediatric Infectious Society

1 - Unidade de Infeciologia, Área da Mulher, Criança e Adolescente, Hospital Dona Estefânia, Centro Hospitalar de Lisboa Central, Lisboa
2 - The Portuguese Study Group of Invasive Pneumococcal Disease The Paediatric Infectious Society

10th World Congress of The World Society for Pediatric Infectious Diseases - WSPID 2017, Comunicação oral

Background: The Portuguese Study Group on IPD conducted a national study in children, in Portugal. The seven-valent pneumococcal conjugate vaccine (PCV7V) was licensed in 2001. PCV10V was introduced in 2009 and PCV13V in 2010 and was included in national immunization program in 2015. The estimated coverage rate was 79% in 2007 and currently is 85%.
Aims: To analyse the incidence, diagnosis, morbidity and mortality in children with IPD in the last eight years.
Methods: National multicenter study, involving 57 hospitals, between May 2008 and May 2016, including all children <18 years with positive culture or PCR for Streptococcus pneumoniae in sterile body fluids.
Results: A total of 801 cases were identified, with an incidence rate of 35,5:100.000 for children <1 year. Diagnosis were meningitis (15.9%), sepsis (7.2%), pneumonia (51.5%), occult bacteraemia (16.7%) and other bacteraemia (7.5%). Complications occurred in 35.9% of the children and the mortality rate was 1.4%. Serotypes 3 and 1 were the most frequently detected (22.5%).Over the last years, we observed an emergence of non-vaccine types (34%) and an increase in the proportion (20.2%) of PVC7 types (6B, 14, 19F, 23F) probably related to the decrease in vaccination rates (from 79% to 58%; due to economic problems in the country), before the introduction of the vaccine in the in national immunization program.
Conclusion: It is extremely important to enforce the ongoing national surveillance of IPD to observe the impactof universal vaccination and to allow for precise and updated recommendations on vaccination strategies.

Palavras Chave: Invasive Pneumococcal Disease (IPD), children